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First synthetic circuit consists of entirely fast, reversible protein-protein interactions Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input. However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions.

Bonnie bergerBrian teagueRon weissTristan beplerDeepak mishraEmily hendersonUniversity of wisconsinArtificial intelligence laboratoryDepartment of biological engineeringDepartment of biochemistryStudy lead authorResearch associateBiological engineeringSimons professorJim broachMolecular biology